- Lofalitsidwa mu Malingaliro a Akatswiri
Lispro yoyendetsedwa ndi jekeseni wopanda singano wa QS-M imapangitsa kuti munthu ayambe kudwala kwambiri insulini kuposa cholembera wamba, komanso kutsitsa shuga koyambirira kokhala ndi mphamvu zofananira.
Cholinga: Cholinga cha phunziroli ndikuwunika mbiri ya pharmacokinetic ndi pharmacodynamic (PK-PD) ya lispro yoyendetsedwa ndi jekeseni wandege wopanda singano wa QS-M m'maphunziro aku China.
Kapangidwe ka kafukufuku ndi njira: Kafukufuku wopangidwa mwachisawawa, wakhungu pawiri, wapawiri, wopitilira muyeso adachitika. Odzipereka athanzi khumi ndi asanu ndi atatu adalembedwa ntchito. Lispro (mayunitsi 0,2 / kg) ankayendetsedwa ndi QS-M singano-free jet jekeseni kapena cholembera ochiritsira. Mayeso a euglycemic clamp a maola asanu ndi awiri adachitidwa. Odzipereka khumi ndi asanu ndi atatu (amuna asanu ndi anayi ndi akazi asanu ndi anayi) adalembedwa mu kafukufukuyu. Njira zophatikizirapo zinali: osasuta azaka za 18-40, okhala ndi index ya thupi (BMI) ya 17-24 kg / m2; anthu omwe ali ndi mayeso achilengedwe achilengedwe, kuthamanga kwa magazi, ndi electrocardiograph; anthu omwe adasaina chilolezo chodziwitsidwa. Njira zosiyanitsira zinali: anthu omwe ali ndi vuto la insulin kapena mbiri ina yosagwirizana; anthu omwe ali ndi matenda osatha monga shuga, matenda amtima, chiwindi kapena impso. Anthu omwe amamwa mowa adachotsedwanso. Kafukufukuyu adavomerezedwa ndi Ethics Committee of the First Affiliated Hospital of Chongqing Medical University.
Zotsatira: Malo okulirapo pansi pa kupindika (AUCs) kwa ndende ya insulini ndi kulowetsedwa kwa shuga (GIR) mkati mwa mphindi 20 zoyambirira pambuyo pa jekeseni wa lispro ndi jekeseni wa jet poyerekeza ndi cholembera cha insulini (24.91 ± 15.25 vs. ± 0.24 vs. 0.10 ± 0.04 U min L-1, P <0.001 kwa AUCINS, 0-20 min). Jekeseni wopanda singano adawonetsa nthawi yayitali kuti afikire kuchuluka kwa insulin (37.78 ± 11.14 vs. 80.56 ± 37.18 min, P <0.001) ndi GIR (73.24 ± 29.89 vs. 116.18 ± 51.89 min, P = 0). Panalibe kusiyana pakuwonetsa kwathunthu kwa insulin komanso zotsatira za hypoglycemic pakati pa zida ziwirizi. Kutsiliza: Lispro yoyendetsedwa ndi jekeseni wopanda singano wa QS-M imapangitsa kuti munthu ayambe kudwala kwambiri insulini kuposa cholembera wamba, komanso kutsitsa shuga koyambirira kofanana ndi mphamvu yonseyi.
Nthawi yotumiza: Apr-29-2022